Leadership Team

Clive A. Meanwell, MD, PhD
Chief Executive Officer

Clive A. Meanwell has been a director since 1996. He has served as our chief executive officer since February 2012, our chief executive officer and president from October 2009 to February 2012, as our chief executive officer from August 2004 to October 2009, as our president from August 2004 to December 2004, our executive chairman from September 2001 to August 2004 and as our chief executive officer and president from 1996 to September 2001. From 1995 to 1996, Dr. Meanwell was a partner and managing director at MPM Capital, L.P., a venture capital firm. From 1986 to 1995, Dr. Meanwell held various positions at Hoffmann-La Roche, Inc., a pharmaceutical company, including senior vice president from 1992 to 1995, vice president from 1991 to 1992 and director of product development from 1986 to 1991. Dr. Meanwell received an M.D. and a Ph.D. from the University of Birmingham, United Kingdom.

Bill O'Connor
Chief Financial Officer

Bill O'Connor has been the Chief Financial Officer of The Medicines Company (MDCO) since January 2016.  Previously, he served as MDCO’s Chief Accounting Officer from 2008 to 2016 and Vice President, Finance and Controller from 2006 to 2008. Before joining MDCO, Bill was the Vice President of Finance for Eyetech Pharmaceuticals, Inc. from 2000 to 2006 and worked in various finance roles at Trophix Pharmaceuticals, Inc. from 1996 to 2000.  Prior to 1996 Bill worked in the public accounting sector for approximately 15 years. Bill is a certified public accountant and received his bachelor’s degree in accounting from Fairleigh Dickinson University.

Jeff Frazier
Executive Vice President

Jeff Frazier joined The Medicines Company (MDCO) in June 2014 as Executive Vice President and Chief Human Strategy Officer. Prior to joining MDCO, Jeff was the Corporate Vice President of Human Resources and Public Affairs at Novo Nordisk Inc. from 2004 to 2014. This leadership translated into Novo Nordisk being named the number one “Best Place to Work” in New Jersey for four out of six years (2004 – 2010), and in being named to the Fortune Magazine "100 Best Companies to Work For" for six consecutive years (2009-2014). Before taking his position at Novo Nordisk, Jeff was head of human resources for Pharmacia Corporation’s Global Pharmaceutical Business unit, where he served as a member of the global commercial leadership team. There he supported international commercial operations of 12,500 employees in 50 countries, through the design and execution of human resources strategy and programs. Prior to that role, he held a number of different senior human resources positions in Europe and in the USA. Jeff received a bachelor’s degree in business administration from Kent State University.

Loretta Itri, MD, FACP
Executive Vice President

Loretta Itri joined The Medicines Company (MDCO) in 2012 and leads Global Health Science and Regulatory Affairs.  Previously, she was President of Pharmaceutical Development and CMO at Genta, Inc., and prior to that she served as Senior Vice President of Medical and Regulatory Affairs at the Robert Wood Johnson Pharmaceutical Research Institute, where she oversaw the development and approval of a variety of therapeutic compounds.  In addition, Loretta served as Senior Vice President of Clinical Affairs and CMO for Ortho Biotech Inc., responsible for the hematology, oncology and immunology product lines.  She began her career in the pharmaceutical industry at Hoffman-La Roche, where she advanced to the position of AVP of Clinical Development in immunology, virology, hematology, and oncology.  Loretta received her medical degree from New York Medical College and completed her medical residency at SUNY-Stony Brook and her fellowship in medical oncology at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York.  She was an adjunct attending physician at MSKCC for over 15 years.  She has served as a member of the National Cancer Institute Board of Scientific Counselors in both the Division of Cancer Treatment and the Division of Cancer Prevention and Control.  Loretta has authored more than 130 original articles, book chapters and abstracts related to the clinical development of therapeutic agents.

Nancye Green
Executive Vice President

Nancye Green leads global communications & information architecture for The Medicines Company (MDCO). A designer and business leader, Nancye has had a storied career addressing the complex communication challenges of large enterprises, startup companies and non-profit organizations across industries. She has designed and produced in multiple media on behalf of clients as diverse as Hoffman-La Roche, 3M, P&G, Exxon, the Ronald Reagan Presidential Library, American Express, Sony and American Girl Place, among many others. In addition, Nancye has founded and/or served as CEO of several businesses, including design firm Donovan/Green and Waterworks, and has served on the boards of directors of several companies, including Waterworks and Hallmark. A recognized leader in her field, she is a past president of the American Institute of Graphic Arts and the prestigious International Design Conference in Aspen. She holds degrees from Tulane University and Parsons School of Design, and was awarded an honorary doctorate from The Corcoran School of Art in Washington, D.C.

Stephanie Plent, MD
Executive Vice President

Stephanie Plent is the head of global health economics at The Medicines Company (MDCO). Prior to joining MDCO in July 2000, Stephanie worked for healthcare provider Aetna for six years developing cardiac centers of excellence programs in conjunction with major cardiovascular hospitals and launching national disease management programs for asthma, diabetes, heart failure and back pain management. In addition, she was a consultant in the healthcare practice of Arthur D. Little based in Cambridge, Massachusetts. Stephanie received her medical degree from the Royal Free Hospital, London UK and completed her general surgical residency at St. Bartholomew's Hospital in London.

Stephen Rodin
Executive Vice President and General Counsel

Stephen Rodin has been general counsel and secretary of The Medicines Company since March 2014. Previously he served as the Company's deputy general counsel from 2010 to 2014 and associate general counsel from 2007 to 2010. Before joining The Medicines Company, Steve was an attorney at the law firm of Proskauer Rose LLP in New York where his practice focused on corporate, commercial and securities law. Steve received an A.B. from Georgetown University and his J.D. from Vanderbilt University Law School.